Grace completed her medical degree in 1992 at the University of Stellenbosch, following which she worked in the British National Health Service.  During this time she specialised as a GP, which provided experience in all levels of hospitals and a variety of general practices, including six months in the Outer Hebrides.  After specialising she worked in urban and semi-urban practices in the UK. 

In 2011, she returned to South Africa to work with COHSASA developing an accreditation programme for General Practices, and later coordinated the development and review of various sets of standards.  In 2015 she joined the Office of Health Standards Compliance as Director: Health Standards Development and Training.  In 2020 she joined the WHO as the National Consultant: Quality Improvement to assist implementation of the National Health Quality Improvement Plan.